Updated: Mar 15
Microglial cells of the Central Nervous System (CNS) are one of many cells that Bartonella has been shown to invade. Migroglial cells are the macrophages of the Central Nervous System. These cells help mediate the CNS immune response by clearing cellular debris, and injured/dead neurons. They are constantly moving to survey the CNS and play a vital role in infection and inflammation. As mentioned previously, Bartonella also invades the vascular endothelial tissue and causes a Small Vessel Inflammatory Disease. Damage can occur to the Central and Peripheral Nervous System, leading to some of the most debilitating symptoms of this disease.
Neurologic Manifestations that have been described include transient aphasia, MS-like disease, meningitis, ice-pick headaches/migraines, tinnitus, photophobia, insomnia, visual disturbances, blurred vision, depression, psychiatric illness, peripheral migratory neuropathy (disease of one or more nerves typically causing numbness and weakness), low pulse pressure, loss of coordination, paresis (weakness), pain syndromes, focal transient muscle fascinations (twitching) and isolated tremors...to name a few!
"B. henselae selectively infects microglial cells in the brain. Microglia are derived from bone marrow precursor cells and serve as the resident tissue macrophages of the nervous system. Previous studies have demonstrated that macrophages can become infected with B. henselae; the organism has been shown to infect murine macrophage-like cells in culture (25), and Warthin-Starry silver staining of lymph node samples from humans with cat scratch disease have identified numerous organisms within tissue macrophages (37). Research into the immune response to B. henselae infection using a rodent model also suggests that macrophages play a role in the pathogenesis of infection. Dissemination via macrophages would provide a means for the organism to enter the CNS, as peripheral blood phagocytes are capable of traversing the blood-brain barrier. Once the organism is inside the brain, infection of local microglial cells may facilitate the development of persistent infections."
Below are some great articles discussing this aspect Bartonellosis.
Bartonella sp. Bacteremia in Patients with Neurological and Neurocognitive Dysfunction. Journal of Clinical Microbiology
Chronic inflammatory demyelinating polyneuropathy as a complication of cat scratch disease, 2000 (scroll to bottom of 1st page)
Neurological and immunological dysfunction in two patients with Bartonella henselae bacteremia. Clinical case reports, 2017
Vasculitis, cerebral infarction and persistent Bartonella henselae infection in a child. Parasites & vectors, 2016:
Spontaneous onset of complex regional pain syndrome Type I in a woman infected with Bartonella koehlerae. Medical microbiology and immunology, 2013: (You have to scroll down a bit for the article)
Neurological Manifestations of Bartonellosis in Immunocompetent Patients: A Composite of Reports from 2005–2012. Journal of Neuroparasitology, 2012